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Pulmotype- clarientinc.com
Pulmotype provides pathologists with a valuable new tool to help their oncologist clients understand which patients are eligible for a number of new therapies now available for the treatment of NSCLC . Its ability to accurately sub-classify lung cancer will enable physicians to make much more informed and effective therapy decisions.
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PI3K Inhibitor- clarientinc.com
The phosphoinositide 3-kinase (PI3K)/AKT1 pathway is acknowledged as a key component of cell survival. Activated by receptors or the small GTPase Ras, the various PI3K isoforms phosphorylate inositol lipids to form second messenger phosphoinositides. PI3K family members have long been accepted as oncogenes.
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KRAS- clarientinc.com
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog also known as KRAS is a protein which in humans is encoded by the KRAS gene. Like other members of the Ras family, the KRAS protein is a GTPase and is an early player in many signal transduction pathways. KRAS is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus.
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EGFR Testing- clarientinc.com
A large body of experimental and clinical work supports the view that EGFR is a relevant target for cancer therapy. The development of selective tyrosine kinase inhibitors has become an important area of drug discovery for the treatment of a variety of solid tumors such as breast, ovarian and colorectal cancers, NSCLC, and carcinoma of the head and neck.
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PI3K- clarientinc.com
The phosphoinositide 3-kinase (PI3K) family is a group of enzymes that generate lipid 'second messengers' that mediate signal transduction. PI3K signaling initiates normal cell processes that are frequently disrupted by carcinogenesis: growth, differentiation (the structure and/or function of a cell is changed), survival, proliferation, migration, metabolism, and metastasis
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PI3K Pathway- clarientinc.com
Activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway, regulates many normal cellular processes which include cell proliferation, survival, and motility. For these same reasons, the PI3K pathway also plays an important oncogenic role in many cancer types. PI3K signaling pathways can be deregulated by a variety of mechanisms in human tumors.
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EGFR- clarientinc.com
The epidermal growth factor receptor (EGFR) is the cell-surface receptor for members of the epidermal growth factor family of extracellular protein ligands. EGFR exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor α.
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